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18 Although the mechanisms dna structure require further clarification, omega-6 and omega-3 fatty acids may regulate gene expression by interacting with specific transcription factors, including peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs).19 Deficiency Essential Fatty Acid Deficiency Clinical signs of essential fatty acid deficiency include a dry scaly rash, decreased dna structure growth in infants and children, increased susceptibility to infection and poor wound healing.20 Omega-3, omega-6 and omega-9 fatty acids compete for the same desaturase enzymes. The desaturase enzymes show preference for the different series of fatty acids in the following order: omega-3 dna structure > omega-6 > omega-9. Consequently, synthesis of the omega-9 fatty acid eicosatrienoic acid (20:3n-9) increases only when dietary intakes of omega-3 and omega-6 fatty acids are very low.21 A plasma eicosatrienoic acid:arachidonic acid (triene:tetraene) ratio greater than 0.2
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