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Brain DHA content may be particularly important, since animal studies have shown that depletion of DHA in the brain can result in learning deficits. It is not clear how text/html;charset=iso 8859-1 DHA affects brain function, but changes in neuronal cell membrane DHA content could alter the function of ion channels or membrane associated receptors, as well as the availability of neurotransmitters.16 Eicosanoid Synthesis Eicosanoids are potent chemical messengers derived text/html;charset=iso 8859-1 from 20-carbon PUFA that play critical roles in immune and inflammatory text/html;charset=iso 8859-1 responses. During an inflammatory response, DGLA, AA and EPA in cell membranes can be metabolized by enzymes known as cyclooxygenases and lipoxygenases to form prostaglandins and leukotrienes, respectively (Figure 2).
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