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Omega-3 Fatty double bond Acid Deficiency At least one case of isolated omega-3 fatty deficiency has been reported. A young girl who received intravenous lipid emulsions with very little ALA developed visual problems and sensory neuropathy, which resolved when she was switched to an emulsion containing more ALA.26 Plasma DHA concentrations decrease when omega-3 fatty acid intake is insufficient, but no cutoff double bond values have been established. Isolated omega-3 fatty acid deficiency does not result in increased double bond plasma triene:tetraene ratios.1 Prevention Visual and Neurological Development Because the last trimester of pregnancy is a critical period for the accumulation of DHA in the brain and retina, preterm infants are thought to be particularly vulnerable to adverse effects of insufficient DHA on visual and neurological development.27 Human milk contains DHA in addition to ALA and EPA, but until recently, ALA was the only omega-3 fatty acid present in conventional infant formulas.
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