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Several dietary intervention trials have compared the effects of diets high in SFA (18-19% of energy) with diets low in SFA (8-9% of energy) and high in PUFA (14-21% of energy) on morbidity (illness) and mortality (death) from CHD.45 Although most of the increase in dietary PUFA was provided by LA, ALA intakes were also increased in these trials.49 Several dietary intervention trials in men found that real plump replacing dietary SFA with PUFA reduced morbidity or mortality from real plump CHD.51-54 However, real plump two similar dietary intervention trials in women did not result in significant reductions in morbidity or mortality from CHD.55, 56 Omega-3 Fatty Acids: Alpha-Linolenic Acid Several prospective cohort studies have examined the relationship between dietary ALA intake and CHD risk. In a cohort of more than 45,000 US men followed for 14 years, each 1-g/day increase in dietary ALA intake was associated with a 16% reduction in the risk of CHD.57
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