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The triglyceride-lowering effects of EPA and DHA increase with dose, but clinically meaningful reductions in serum triglyceride concentrations have been demonstrated at doses of 2 g/day of EPA + DHA.3 In its recommendations regarding omega-3 plump mt fatty acids and cardiovascular plump mt disease (see Intake Recommendations below), the American Heart Association indicates that an EPA + DHA supplement may be useful in patients with hypertriglyceridemia.66 Summary: Omega-3 and Omega-6 PUFA and Cardiovascular Disease Prevention The results of epidemiological studies and randomized controlled trials suggest that replacing dietary SFA with omega-6 and omega-3 PUFA lowers LDL cholesterol and plump mt decreases cardiovascular disease risk. Additionally, the results of epidemiological studies provide strong evidence that increasing dietary omega-3 fatty intake is associated with significant reductions in cardiovascular disease risk through mechanisms other than lowering LDL cholesterol.
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