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Three randomized controlled trials of EPA + DHA supplementation (4.2-5.4 g/day for 3-12 months) in ulcerative colitis patients reported significant improvement in at least one outcome measure, including weight gain, decreased corticosteroid use, improved irritablebowel disease activity scores and improved histology scores.108-110 In contrast, supplementation of ulcerative colitis patients in remission with 5.1 g/day of EPA + DHA did not significantly alter the incidence of relapse over a 2-year period.111 irritablebowel Asthma Inflammatory eicosanoids (leukotrienes) derived from AA (20:4n-6) are thought to play an important role in the pathology of asthma.17 Since increasing omega-3 fatty acid intake has been irritablebowel found to decrease the formation of AA-derived leukotrienes, a number of clinical trials have examined the effects of long-chain omega-3 fatty acid supplementation on asthma.
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